The importance of vitamins and minerals and the role of Supradyn

Vitamins and minerals play a role in the synthesis and recycling of ATP (adenosine triphosphate) – an organic compound that provides energy to drive many processes in living cells. In other words, it is the body’s universal “energy currency,” but it cannot be stored in an amount larger than around 50 grams.

At the same time, an adult human body uses up to its weight of ATP daily and up to 3x more in times of more intense energy use. Supradyn is a multivitamin supplement containing all fundamental vitamins and minerals, which support your organism in many physiological processes, including Energy production and protect cells from damage, such as the one caused by oxidative stress. Insufficient intake of micronutrients may have negative effects on energy metabolism and result in symptoms of fatigue. Especially detrimental is the B group vitamins insufficiency, which are actively participating in metabolic reactions and energy production. It has been shown that supplementation with Supradyn increases energy expenditure and cerebral blood flow, improves nutritional status and thus decreases tiredness. Supradyn also improves performance during cognitive multitasking and attenuates the tiredness associated with it.8-11

Did you know that…

  • up to 45% of the population report the feeling of low energy, fatigue, and tiredness?1
  • …micronutrients deplete faster in people with active lifestyle?4
  • …an insufficient level of already 1 micronutrient can lead to tiredness?2

The role of vitamins and minerals in the energy metabolism

  • Vitamins and minerals are required during this process as cofactors or structural components of the enzymes and are necessary for the generation of ATP 1
  • As different vitamins and minerals are involved in different steps, a combination of all micronutrients is needed to generate energy2

Vitamins and minerals in Supradyn®

  • Supradyn contains up to 300% of the RDA (recommended daily allowance) of the water-soluble vitamins.
  • Specifically:
    • 13 vitamins: vitamin A, vitamin B1, vitamin B2, vitamin B3 (Niacin), vitamin B5 (pantothenic acid), vitamin B6, vitamin B7 (Biotin), vitamin B9 (Folic acid), vitamin B12, vitamin C, vitamin D3, vitamin E, vitamin K
    • 9 minerals and trace elements: calcium (Ca), copper (Cu), iodine (I), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), selenium (Se), zinc (Zn)
    • Coenzyme Q10 (CoQ10).

These are important for:

  • Vitamin A is essential for the metabolic fitness of the mitochondria.2
  • Magnesium enhances the activity of enzymes in the mitochondria involved in energy metabolism. 3
  • Calcium stimulates both glycogen breakdown and glucose oxidation leading to increased ATP supply. 4
  • Iron increases the activity of enzymes in the citric acid cycle (CAC) leading to increased ATP formation.5
  • Vitamins C, E, K1, selenium, zinc, and copper are antioxidants. They prevent other cells from oxidative damage caused by excessive production of reactive oxygen species (ROS) resulting from oxidative phosphorylation in the mitochondria. 6, 8
  • Iodine and selenium are important for metabolism of thyroid hormones. Amongst other, thyroid
  • hormones are potent activators of mitochondriogenesis9,10
  • Vitamin D improves oxidative phosphorylation.11
  • Coenzyme Q10 supports mitochondrial ATP production in the respiratory chain. Vitamin K1 has a similar chemical structure and it is proposed that it mimics CoQ10’s supporting effect on ATP synthesis.12

Vitamins and minerals in Supradyn®

  • Metabolic reactions and energy production (B1, B2, B3, B6, B12, B7, B5, C, K, iron, copper, manganese, molybdenum, B9, zinc, CoQ10)6,9
  • They act as cofactors for different enzymes, meaning they are non-protein parts of enzymes essential for enzymatic function6,9

The effects of Supradyn supplementation

  • improves micronutrient status8,9,10,11
  • increases the amount of energy released by the body (after 1 intake)10,11
  • reduces tiredness/fatigue and oxidative stress9
  • improves physical and cognitive performance8,9,10


  1. Ricci, J. A., Chee, E., Lorandeau, A. L., & Berger, J. (2007). Fatigue In The U.S. Workforce: Prevalence And Cost Of Lost Productive Work Time. JOEM, 49(1). doi:10.1097/01.jom.0000249782.60321.2a
  2. Huskisson, E., Maggini, S., & Ruf, M. (2007). The Role of Vitamins and Minerals in Energy Metabolism and Well-Being. Journal of International Medical Research, 35(3), 277-289. doi:10.1177/147323000703500301
  3. Carbohydrates. (2005). Journal of Pediatric Gastroenterology and Nutrition, 41(S2), S28-S32. doi:10.1097/01.mpg.0000181845.16499.a8
  4. Wishart, K. (2017). Increased Micronutrient Requirements during Physiologically Demanding Situations: Review of the Current Evidence. Vitamins & Minerals, 06(03). doi:10.4172/2376-1318.1000166
  5. Troesch, B., Hoeft, B., Mcburney, M., Eggersdorfer, M., & Weber, P. (2012). Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. British Journal of Nutrition, 108(04), 692-698. doi: 10.1017/s0007114512001808
  6. Grisham, C. M. (2010). Thermodynamics of Biological Systems. In R. H. Garrett (Author), Biochemistry (4th ed., pp. 48-69). Boston, MA: Brooks/Cole, Cengage Learning.
  7. Ainsworth, B. E., Haskell, W. L., Whitt, M. C., Irwin, M. L., Swartz, A. M., Strath, S. J., . . . Leon, A. R. (2000). Compendium of Physical Activities: An update of activity codes and MET intensities. Medicine & Science in Sports & Exercise, 32(9 Suppl), S498-S516.
  8. Haskell CF, Robertson B, Jones E, et al. Effects of a multi-vitamin/mineral supplement on cognitive function and fatigue
  9. Maric, D., Brkic, S., Novakov Mikic, A., et al. (2014). Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Medical Science Monitor, 20:47-53. doi: 10.12659/MSM.889333
  10. Dodd, F.L., Kennedy, D.O., Stevenson, E.J. et al. Acute and chronic effects of multivitamin/mineral supplementation on objective and subjective energy measures. Nutr Metab (Lond) 17, 16 (2020).
  11. Kennedy DO, Stevenson EJ, Jackson PA, et al. Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: A double-blind, randomised, placebo-controlled trial. Nutr Metab (Lond). 2016;13:11.
  12. Huskisson E, Maggini S, Ruf M. The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res. 2007;35(3):277-289.